Dynamic Mathematical Modeling of IL13-induced Signaling in Hodgkin and Primary Mediastinal B-cell Lymphoma Allows Prediction of Therapeutic Targets Authors and Affiliations
نویسندگان
چکیده
Division of Systems Biology of Signal Transduction, DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), Heidelberg, Germany Molecular Structural Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany Computational Modeling in Biology, Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München, München, Germany Physics Institute, University of Freiburg, Freiburg, Germany Medical Research Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany Institute of Pathology, Ulm University Clinic, Ulm, Germany Freiburg Institute for Advanced Studies, University of Freiburg, Freiburg, Germany Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany Running title Modeling of IL13-induced signaling in two lymphoma entities
منابع مشابه
Allows Prediction of Therapeutic Targets in Hodgkin and Primary Mediastinal B-Cell Lymphoma Dynamic Mathematical Modeling of IL13-Induced Signaling
Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of JAK (Janus kinase)/STAT signaling pathway. Because of complex, nonlinear relations within the pathway, key dynamic properties remained to be identified to predict possible strategies for intervention. We report the development of dynamic pathway models based on quantitativ...
متن کاملDynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets.
Primary mediastinal B-cell lymphoma (PMBL) and classical Hodgkin lymphoma (cHL) share a frequent constitutive activation of JAK (Janus kinase)/STAT signaling pathway. Because of complex, nonlinear relations within the pathway, key dynamic properties remained to be identified to predict possible strategies for intervention. We report the development of dynamic pathway models based on quantitativ...
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